What is leaky gut?

Leaky gut – when the small intestine doesn’t hold tight

Unlike the large intestine, the small intestine lacks a protective mucus layer, making it more sensitive—especially when there’s bacterial overgrowth in the small intestine (SIBO). This allows bacteria and toxins to more easily come into direct contact with the intestinal wall and activate immune receptors on the intestinal cells. This can trigger inflammation, which may cause the gut wall to suddenly allow substances to pass through that would normally be kept out. This condition is known as leaky gut.

How does leaky gut develop?

When bacteria and toxins come into direct contact with the intestinal wall and activate immune receptors, inflammation can occur. It is primarily this inflammation that causes the gut to become "leaky," although the bacteria and toxins themselves can also contribute to and worsen the condition.

Common causes of leaky gut:

  • Bacterial overgrowth in the small intestine (SIBO) is found in most cases of leaky gut
  • Chronic stress
  • Long-term use of omeprazole or other long term acid-reducing medications
  • High intake of sugar, alcohol, or processed foods

What happens in the body with leaky gut?

When the intestinal wall becomes permeable, bacteria and toxins can leak into the bloodstream and lymphatic system. This can:

  • Disrupt the immune system and cause chronic low-grade inflammation
  • Affect the gut’s nervous system, leading to symptoms like bloating, pain, and diarrhea
  • Spread through the bloodstream and contribute to systemic health problems such as skin issues, joint pain, brain fog, metabolic issues and fatigue.

Signs of leaky gut

Since around 70% of the body's immune cells reside in the mucosa of the small intestine, a leaky gut can disrupt immune function and also affect the nervous system. Over time, this can contribute to a wide range of health issues.

Local digestive symptoms:

  • Bloating
  • Excessive gas
  • Diarrhea and/or constipation
  • Abdominal cramps
  • Food intolerances or sensitivities (e.g., to gluten or lactose)

General symptoms:

  • Fatigue and brain fog: Trouble concentrating or feeling mentally clear
  • Joint and muscle pain: Inflammation may cause diffuse pain
  • Skin issues: Eczema, rosacea, acne, or psoriasis may sometimes be linked to gut health

Immune-related symptoms:

  • Recurring infections or weakened immune function
  • Food sensitivities
  • Autoimmunity

Psychological symptoms:

  • Anxiety
  • Depression or low mood
  • Irritability

Other symptoms:

  • Headaches or migraines
  • Weight gain or difficulty losing weight
  • Blood sugar imbalances

Help for leaky gut

First and foremost, it's important to identify the underlying cause. Bacterial overgrowth (SIBO) is common, but your symptoms could also be related to food sensitivities, histamine intolerance, or other factors. Understanding the root cause will determine the best treatment strategy. As a starting point, a range of natural supplements combined with lifestyle changes can offer good results.

If your leaky gut is related to SIBO, we recommend GutClear®, our own plant-based supplement designed to support healthy gut function in cases of SIBO and leaky gut.

Did you know you can test for leaky gut?

Gutfeeling Labs offers a new, patent-pending test for leaky gut and SIBO.
This test is completely unique on the market because it’s a urine test rather than a breath test. This makes sample collection much simpler and provides significantly higher sensitivity in detecting the presence of bacteria in the small intestine compared to older methods. With this test, you receive quick results and clear answers as to whether leaky gut and/or SIBO might be behind your symptoms—along with tailored advice based on your results.

Get to the root of your gut issues

Test for Leaky Gut and SIBO

A newly developed and exceptionally reliable urine test for those who want a clear answer to determine if they have leaky gut and/or SIBO – quickly and easily. This is a simple and trustworthy way to get fast test results – along with helpful guidance and recommendations. SIBO is found in 80% of people with IBS and is also a common cause of leaky gut.

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50% summer discount with the code summer2025 until August 31 (activate the code using the “Apply” button to the right of the discount field)

International delivery to your mailbox 5-10 working days after ordering